Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Epidermal growth factor receptor [T790M,L858R] | ||
| Ligand | BDBM50379214 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 303.15±n/a K | ||
| IC50 | 2800±n/a nM | ||
| Comments | extracted | ||
| Citation |  Burnet, MW; Thaher, BA; Ehlert, J; Kubbutat, M; Schaechtele, C; Totzke, F Kinase modulators for the treatment of cancer US Patent US9416123 Publication Date 8/16/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Epidermal growth factor receptor [T790M,L858R] | |||
| Name: | Epidermal growth factor receptor [T790M,L858R] | ||
| Synonyms: | EGFR | EGFR (L858R, T790M) | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) (T790M/L858R) | Epidermal growth factor receptor (EGFR)(T790M/L858R) | Epidermal growth factor receptor (T790M)(L858R) | Epidermal growth factor receptor (T790M, L858R) | Epidermal growth factor receptor (T790M/L858R) | Epidermal growth factor receptor(L858R, T790M) | HER1 | ||
| Type: | n/a | ||
| Mol. Mass.: | 134353.72 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P00533[T790M,L858R] | ||
| Residue: | 1210 | ||
| Sequence: |
| ||
| BDBM50379214 | |||
| n/a | |||
| Name | BDBM50379214 | ||
| Synonyms: | CHEMBL2011291 | US9416123, 6 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H12Cl3FN4 | ||
| Mol. Mass. | 433.693 | ||
| SMILES | Nc1c(c(nn1-c1c(Cl)cc(Cl)cc1Cl)-c1ccncc1)-c1ccc(F)cc1 |(-1,-2.52,;-1.47,-1.05,;-2.94,-.58,;-2.94,.96,;-1.47,1.44,;-.56,.19,;.98,.19,;1.74,1.52,;.97,2.85,;3.28,1.52,;4.06,.18,;5.6,.18,;3.29,-1.15,;1.75,-1.15,;.97,-2.48,;-4.18,1.87,;-4.2,3.41,;-5.54,4.16,;-6.87,3.37,;-6.84,1.82,;-5.5,1.08,;-4.18,-1.48,;-5.52,-.72,;-6.85,-1.5,;-6.84,-3.04,;-8.17,-3.82,;-5.49,-3.8,;-4.17,-3.02,)| | ||
| Structure | 
| ||