| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein [1973-2419] |
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| Ligand | BDBM241826 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Luciferase Assay |
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| EC50 | 0.016±n/a nM |
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| Citation |  Zhang, J; Zhang, Y; Xie, H; Ren, Q; Hu, B; Fu, C; Wu, X; Li, S; Wang, C; Zhang, Z Spiro ring compound as hepatitis C virus (HCV) inhibitor and uses thereof US Patent US9416139 Publication Date 8/16/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Genome polyprotein [1973-2419] |
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| Name: | Genome polyprotein [1973-2419] |
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| Synonyms: | Non-structural protein 5A (NS5A) | POLG_HCVCO | RNA-directed RNA polymerase (NS5B) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48705.67 |
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| Organism: | Hepatitis C virus genotype 1b (isolate Con1) (HCV) |
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| Description: | Q9WMX2[1973-2419] |
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| Residue: | 447 |
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| Sequence: | SGSWLRDVWDWICTVLTDFKTWLQSKLLPRLPGVPFFSCQRGYKGVWRGDGIMQTTCPCG
AQITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVE
VTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLN
QYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLK
ATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPA
EILRRSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRT
VVLSESTVSSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLE
GEPGDPDLSDGSWSTVSEEASEDVVCC
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| BDBM241826 |
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| n/a |
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| Name | BDBM241826 |
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| Synonyms: | US9416139, 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C54H66N8O7 |
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| Mol. Mass. | 939.1512 |
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| SMILES | COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(cc1)-c1ccc(c2CC3(CCCC3)Cc12)-c1ccc2c(c1)N=C(NC21COC1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r,c:53| |
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| Structure | 
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