| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein [2420-3010] |
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| Ligand | BDBM241866 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Polymerase Inhibition Assay |
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| pH | 7.3±n/a |
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| Temperature | 298.15±n/a K |
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| EC50 | 13000±n/a nM |
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| Comments | extracted |
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| Citation |  Verma, VA; Arasappan, A; Njoroge, FG; Girijavallabhan, V; Bogen, SL; Dang, Q; Olsen, DB 5′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases US Patent US9416154 Publication Date 8/16/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Genome polyprotein [2420-3010] |
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| Name: | Genome polyprotein [2420-3010] |
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| Synonyms: | POLG_HCVBK | RNA-directed RNA polymerase (NS5B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 65648.71 |
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| Organism: | Hepatitis C virus genotype 1b (isolate BK) (HCV) |
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| Description: | aa 2420-3010 |
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| Residue: | 591 |
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| Sequence: | SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQKKVTFDRLQVL
DDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIH
SVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS
TLPQVVMGSSYGFQYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIY
QCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAS
AACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLW
ARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPG
EINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIP
AASRLDLSGWFVAGYSGGDIYHSLSRARPRWFMLCLLLLSVGVGIYLLPNR
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| BDBM241866 |
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| n/a |
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| Name | BDBM241866 |
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| Synonyms: | US9416154, 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H40N5O8P |
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| Mol. Mass. | 641.6518 |
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| SMILES | CCCCOC(=O)[C@H](C)NP(=O)(O[C@H](CC)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1cccc2ccccc12 |r| |
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| Structure | 
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