Reaction Details |
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Target | Genome polyprotein [2420-3010] |
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Ligand | BDBM241891 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Polymerase Inhibition Assay |
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pH | 7.3±n/a |
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Temperature | 298.15±n/a K |
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EC50 | 18000±n/a nM |
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Comments | extracted |
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Citation | Verma, VA; Arasappan, A; Njoroge, FG; Girijavallabhan, V; Bogen, SL; Dang, Q; Olsen, DB 5′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases US Patent US9416154 Publication Date 8/16/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Genome polyprotein [2420-3010] |
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Name: | Genome polyprotein [2420-3010] |
Synonyms: | POLG_HCVBK | RNA-directed RNA polymerase (NS5B) |
Type: | Enzyme |
Mol. Mass.: | 65648.71 |
Organism: | Hepatitis C virus genotype 1b (isolate BK) (HCV) |
Description: | aa 2420-3010 |
Residue: | 591 |
Sequence: | SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQKKVTFDRLQVL
DDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIH
SVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS
TLPQVVMGSSYGFQYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIY
QCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAS
AACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLW
ARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPG
EINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIP
AASRLDLSGWFVAGYSGGDIYHSLSRARPRWFMLCLLLLSVGVGIYLLPNR
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BDBM241891 |
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n/a |
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Name | BDBM241891 |
Synonyms: | US9416154, 41 |
Type | Small organic molecule |
Emp. Form. | C27H38N5O8P |
Mol. Mass. | 591.5931 |
SMILES | C[C@H](NP(=O)(OC(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1ccccc1)C(=O)OCC(C)(C)C |r| |
Structure |
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