| Reaction Details |
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 | Report a problem with these data |
| Target | Carboxylic ester hydrolase |
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| Ligand | BDBM50022775 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AChE and BuChE Activity Assay |
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| pH | 8±n/a |
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| Temperature | 275.15±n/a K |
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| IC50 | 70±9.0 nM |
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| Comments | extracted |
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| Citation |  Skrzypek, A; Matysiak, J; Karpinska, MM; Niewiadomy, A Synthesis and anticholinesterase activities of novel 1,3,4-thiadiazole based compounds. J Enzyme Inhib Med Chem28:816-23 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carboxylic ester hydrolase |
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| Name: | Carboxylic ester hydrolase |
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| Synonyms: | BuChE | Butyrlcholinesterase (BuChE) | Butyrylcholine esterase | Butyrylcholinesterase | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | Butyrylcholinesterase (EqBuChE) | Carboxylic ester hydrolase | butyrylcholinesterase precursor |
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| Type: | Protein |
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| Mol. Mass.: | 68842.83 |
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| Organism: | Equus caballus (Horse) |
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| Description: | Q9N1N9 |
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| Residue: | 602 |
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| Sequence: | MQSWGTIICIRILLRFLLLWVLIGNSHTEEDIIITTKNGKVRGMNLPVLGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSNIWNATKYANSCYQNTDQSFPGFLGSEMWNPNTELSEDC
LYLNVWIPAPKPKNATVMIWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGALG
FLALSENPEAPGNMGLFDQQLALQWVQKNIAAFGGNPRSVTLFGESAGAASVSLHLLSPR
SQPLFTRAILQSGSSNAPWAVTSLYEARNRTLTLAKRMGCSRDNETEMIKCLRDKDPQEI
LLNEVFVVPYDTLLSVNFGPTVDGDFLTDMPDTLLQLGQFKRTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPRVSEFGRESILFHYMDWLDDQRAENYREALDDV
VGDYNIICPALEFTKKFSELGNDAFFYYFEHRSTKLPWPEWMGVMHGYEIEFVFGLPLER
RVNYTKAEEILSRSIMKRWANFAKYGNPNGTQSNSTRWPVFKSTEQKYLTLNTESPKVYT
KLRAQQCRFWTLFFPKVLELTGNIDEAEREWKAGFHRWNNYMMDWKNQFNDYTSKKESCS
DF
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| BDBM50022775 |
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| n/a |
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| Name | BDBM50022775 |
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| Synonyms: | (m-Hydroxyphenyl)trimethylammonium dimethylcarbamate | 3-Trimethylammoniumphenyl N,N-dimethylcarbamate | 3-[(dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium | CHEMBL211471 | CHEMBL278020 | Eustigmin | Eustigmine | NEOSTIGMINE | Neostigmine (2) | Prostigmine | Vagostigmine | m-Trimethylammoniumphenyldimethylcarbamate |
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| Type | Small organic molecule |
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| Emp. Form. | C12H19N2O2 |
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| Mol. Mass. | 223.2909 |
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| SMILES | CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C |
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| Structure | 
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