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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase pim-1 | ||
| Ligand | BDBM242354 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase-Glo Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 9±n/a nM | ||
| Comments | extracted | ||
| Citation |  Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, M; Ho, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent US9416132 Publication Date 8/16/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase pim-1 | |||
| Name: | Serine/threonine-protein kinase pim-1 | ||
| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) | ||
| Type: | Protein | ||
| Mol. Mass.: | 35681.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11309 | ||
| Residue: | 313 | ||
| Sequence: |
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| BDBM242354 | |||
| n/a | |||
| Name | BDBM242354 | ||
| Synonyms: | US10047093, 8-10 | US10392392, Example 8-10 | US10875864, EX. 8-10 | US9416132, 8-10 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H25F3N4O2 | ||
| Mol. Mass. | 434.4547 | ||
| SMILES | CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:7.10,wD:4.3,(-9.24,2.08,;-7.91,2.85,;-7.91,4.39,;-9.24,3.62,;-6.57,2.08,;-6.57,.54,;-5.24,-.23,;-3.91,.54,;-3.91,2.08,;-5.24,2.85,;-2.57,-.23,;-1.24,.54,;-1.24,2.08,;.09,2.85,;1.43,2.08,;2.89,2.56,;3.8,1.31,;2.89,.07,;3.29,-1.42,;2.2,-2.51,;2.6,-4,;4.09,-4.39,;5.23,-3.32,;6.72,-3.72,;7.81,-2.63,;8.9,-1.54,;8.9,-3.72,;6.72,-1.54,;4.78,-1.82,;1.43,.54,;.09,-.23,)| | ||
| Structure | 
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