| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase Src |
|---|
| Ligand | BDBM243040 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitor Src Tyrosine Kinase Activity Assay |
|---|
| Temperature | 295.15±0 K |
|---|
| IC50 | 1.6e+4±n/a nM |
|---|
| Citation |  Dincer, S; Cetin, KT; Onay-Besikci, A; Ölgen, S Synthesis, biological evaluation and docking studies of new pyrrolo[2,3-d] pyrimidine derivatives as Src family-selective tyrosine kinase inhibitors. J Enzyme Inhib Med Chem28:1080-7 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Proto-oncogene tyrosine-protein kinase Src |
|---|
| Name: | Proto-oncogene tyrosine-protein kinase Src |
|---|
| Synonyms: | Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 59838.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P12931 |
|---|
| Residue: | 536 |
|---|
| Sequence: | MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
|
|
|
|---|
| BDBM243040 |
|---|
| n/a |
|---|
| Name | BDBM243040 |
|---|
| Synonyms: | N-[(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]-5-methylthiophene-2-carboxamide (7) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H13N5O2S |
|---|
| Mol. Mass. | 303.34 |
|---|
| SMILES | Cc1ccc(s1)C(=O)NCc1c[nH]c2nc(N)[nH]c(=O)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
