| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Genome polyprotein [1973-2419,L2000T] |
|---|
| Ligand | BDBM243438 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Transient Replicon Assay |
|---|
| EC50 | 0.117±n/a nM |
|---|
| Citation |  Vandyck, K; Last, SJ; Houpis, IN; Raboisson, PJ Benzimidazole-imidazole derivatives US Patent US9427428 Publication Date 8/30/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Genome polyprotein [1973-2419,L2000T] |
|---|
| Name: | Genome polyprotein [1973-2419,L2000T] |
|---|
| Synonyms: | Non-structural protein 5A (NS5A)(L28T) | POLG_HCVCO | Serine protease NS5A (L28T) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48693.61 |
|---|
| Organism: | Hepatitis C virus genotype 1b (isolate Con1) (HCV) |
|---|
| Description: | aa 1973-2419 |
|---|
| Residue: | 447 |
|---|
| Sequence: | SGSWLRDVWDWICTVLTDFKTWLQSKLTPRLPGVPFFSCQRGYKGVWRGDGIMQTTCPCG
AQITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVE
VTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLN
QYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLK
ATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPA
EILRRSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRT
VVLSESTVSSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLE
GEPGDPDLSDGSWSTVSEEASEDVVCC
|
|
|
|---|
| BDBM243438 |
|---|
| n/a |
|---|
| Name | BDBM243438 |
|---|
| Synonyms: | US9427428, 11 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C42H50N8O7 |
|---|
| Mol. Mass. | 778.8958 |
|---|
| SMILES | CO[C@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@H](NC(=O)OC)C(C)C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
