| Reaction Details |
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 | Report a problem with these data |
| Target | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
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| Ligand | BDBM244219 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Activation Assay |
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| Temperature | 310.15±n/a K |
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| EC50 | 24±n/a nM |
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| Comments | extracted |
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| Citation |  Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T Bicyclic nitrogen-containing aromatic heterocyclic amide compound US Patent US9428501 Publication Date 8/30/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
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| Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
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| Synonyms: | AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 62331.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P54646 |
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| Residue: | 552 |
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| Sequence: | MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK
IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF
QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA
APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS
VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF
ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP
PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY
RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR
SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF
EMCASLITTLAR
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| BDBM244219 |
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| n/a |
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| Name | BDBM244219 |
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| Synonyms: | US9428501, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H35F3N6O2 |
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| Mol. Mass. | 592.6545 |
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| SMILES | COc1ccc(CN2CCC(CC2)c2ccc3[nH]c(nc3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1 |
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| Structure | 
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