| Reaction Details |
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 | Report a problem with these data |
| Target | Triosephosphate isomerase |
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| Ligand | BDBM246596 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.4±0 |
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| Temperature | 310.15±0 K |
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| IC50 | 1.00e+5±n/a nM |
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| Citation |  Alvarez, G; Martínez, J; Aguirre-López, B; Cabrera, N; Pérez-Díaz, L; de Gómez-Puyou, MT; Gómez-Puyou, A; Pérez-Montfort, R; Garat, B; Merlino, A; González, M; Cerecetto, H New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition. J Enzyme Inhib Med Chem29:198-204 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Triosephosphate isomerase |
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| Name: | Triosephosphate isomerase |
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| Synonyms: | TIM | TPI | TPI1 | TPIS_HUMAN | Triose-phosphate isomerase | Triosephosphate isomerase | Triosephosphate isomerase (TIM) |
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| Type: | Enzyme |
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| Mol. Mass.: | 30788.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P60174 |
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| Residue: | 249 |
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| Sequence: | MAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKI
AVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAE
GLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQ
QAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPE
FVDIINAKQ
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| BDBM246596 |
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| n/a |
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| Name | BDBM246596 |
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| Synonyms: | TIM inhibitor, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H8N2OS |
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| Mol. Mass. | 192.238 |
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| SMILES | Cc1ccc(cc1)-c1nsc(=O)[nH]1 |
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| Structure | 
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