| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 3A4 |
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| Ligand | BDBM247971 |
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| Substrate/Competitor | US9434724, Midazolam |
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| Meas. Tech. | Cytochrome P450 Inhibition |
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| Temperature | 310.15±n/a K |
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| IC50 | >10000±n/a nM |
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| Comments | extracted |
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| Citation |  Bilcer, GM; Ng, R Quinuclidines for modulating alpha 7 activity US Patent US9434724 Publication Date 9/6/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Cytochrome P450 3A4 |
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| Name: | Cytochrome P450 3A4 |
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| Synonyms: | Albendazole monooxygenase | Albendazole sulfoxidase | CP3A4_HUMAN | CYP3A3 | CYP3A4 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 3A4 (CYP3A4) | Cytochrome P450 HLp | Nifedipine oxidase | Quinine 3-monooxygenase | Taurochenodeoxycholate 6-alpha-hydroxylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 57349.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 503 |
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| Sequence: | MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
GLLQPEKPVVLKVESRDGTVSGA
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| BDBM247971 |
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| US9434724, Midazolam |
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| Name | BDBM247971 |
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| Synonyms: | US9434724, 53 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19BrN2O3 |
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| Mol. Mass. | 379.248 |
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| SMILES | Oc1cc(Br)c2c(c[nH]c2c1)C(=O)OCC12CCN(CC1)CC2 |
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| Structure | 
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