Ki Summary

Reaction Details

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Target

Histamine receptor H3

Ligand

BDBM247455

Substrate/Competitor

n/a

Meas. Tech.

Radioligand Binding Assay

6.61±n/a nM

Citation

Gao, Z Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof US Patent US9453023 Publication Date 9/27/2016

More Info.:

Get all data from this article, Assay Method

Histamine receptor H3

Name:

Histamine receptor H3

Synonyms:

n/a

Type:

Enzyme

Mol. Mass.:

48611.84

Organism:

Macaca mulatta (Rhesus macaque)

Description:

Q865E1

Residue:

445

Sequence:

MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAG
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEQCWK

BDBM247455

n/a

Name

BDBM247455

Synonyms:

US9453023, 14

Type

Small organic molecule

Emp. Form.

C30H44FN3O3

Mol. Mass.

513.6871

SMILES

C[C@@H]1CCCN1[C@H]1CC[C@@H](CC1)c1ccc(N2CCC3(CCN(CC3)C(=O)OC(C)(C)C)C2=O)c(F)c1 |r,wU:9.13,1.0,wD:6.6,(9.66,-3.21,;10.43,-1.88,;11.9,-1.41,;11.9,.13,;10.43,.61,;9.53,-.64,;7.99,-.64,;7.22,.7,;5.68,.7,;4.91,-.64,;5.68,-1.97,;7.22,-1.97,;3.37,-.64,;2.6,-1.97,;1.06,-1.97,;.29,-.64,;-1.25,-.64,;-1.73,-2.1,;-3.27,-2.1,;-3.74,-.64,;-5.08,-1.41,;-6.41,-.64,;-6.41,.9,;-5.08,1.67,;-3.74,.9,;-7.74,1.67,;-7.74,3.21,;-9.08,.9,;-10.41,1.67,;-10.81,3.16,;-11.9,2.07,;-11.5,.59,;-2.5,.27,;-2.5,1.81,;1.06,.7,;.29,2.03,;2.6,.7,)|

Structure