| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Casein kinase II subunit alpha/beta |
|---|
| Ligand | BDBM248079 |
|---|
| Substrate/Competitor | BDBM248093 |
|---|
| Meas. Tech. | In Vitro Kinase Assay |
|---|
| pH | 7.5±0 |
|---|
| Temperature | 303.15±0 K |
|---|
| IC50 | >3.0e+4±n/a nM |
|---|
| Citation |  Chekanov, MO; Ostrynska, OV; Synyugin, AR; Bdzhola, VG; Yarmoluk, SM Design, synthesis and evaluation of 2-phenylisothiazolidin-3-one-1,1-dioxides as a new class of human protein kinase CK2 inhibitors. J Enzyme Inhib Med Chem29:338-43 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Casein kinase II subunit alpha/beta |
|---|
| Name: | Casein kinase II subunit alpha/beta |
|---|
| Synonyms: | Casein kinase 2 (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha alpha beta beta | Complex of catalytic (CK2α) and non-catalytic (CK2β) subunits |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 989485 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Casein kinase II subunit alpha |
|---|
| Synonyms: | CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45151.12 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P68400 |
|---|
| Residue: | 391 |
|---|
| Sequence: | MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD
QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT
PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
|
|
|
|---|
| Component 2 |
| Name: | Casein kinase II subunit beta |
|---|
| Synonyms: | CK II beta | CSK2B_RAT | Casein kinase II beta | Casein kinase II subunit beta | Ck2n | Csnk2b | Phosvitin |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 24937.13 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | EBI_10969 |
|---|
| Residue: | 215 |
|---|
| Sequence: | MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDE
ELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPML
PIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPA
NQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR
|
|
|
|---|
| BDBM248079 |
|---|
| BDBM248093 |
|---|
| Name | BDBM248079 |
|---|
| Synonyms: | 5-{[4-(4,4-dimethyl-1,1-dioxido-3-oxoisothiazolidin-2-yl)benzoyl]amino}-2-hydroxybenzoic acid (29) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H18N2O7S |
|---|
| Mol. Mass. | 418.42 |
|---|
| SMILES | CC1(C)CS(=O)(=O)N(C1=O)c1ccc(cc1)C(=O)Nc1ccc(O)c(c1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
