| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hexokinase-4 |
|---|
| Ligand | BDBM249159 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Glucokinase-Activating Assay |
|---|
| Temperature | 303.15±n/a K |
|---|
| EC50 | 23.5±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Lin, S; Zhang, R; Campbell, B; Dewnani, SV; Xu, J; Xu, L; Parmee, ER; Kats-Kagan, R Glucokinase activator compounds, compositions containing such compounds, and methods of treatment US Patent US9453038 Publication Date 9/27/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hexokinase-4 |
|---|
| Name: | Hexokinase-4 |
|---|
| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52175.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P35557 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
|
|
|
|---|
| BDBM249159 |
|---|
| n/a |
|---|
| Name | BDBM249159 |
|---|
| Synonyms: | US9453038, 37 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H31N4O7PS2 |
|---|
| Mol. Mass. | 618.661 |
|---|
| SMILES | CCOP(=O)(Cc1cnc(s1)-c1cc2cc(Oc3ccc(nc3)S(C)(=O)=O)c(cc2[nH]1)C1CCC(=O)N1C)OCC |
|---|
| Structure | 
|
|---|
Search and Browse
