| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein [2420-3010] |
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| Ligand | BDBM249180 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cell-Based HCV Replicon Assay |
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| Temperature | 321.15±n/a K |
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| EC50 | >100000±n/a nM |
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| Comments | extracted |
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| Citation |  Girijavallabhan, V; Bogen, S; Pan, W; Dang, Q; Davies, I 2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases US Patent US9457039 Publication Date 10/4/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Genome polyprotein [2420-3010] |
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| Name: | Genome polyprotein [2420-3010] |
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| Synonyms: | POLG_HCVBK | RNA-directed RNA polymerase (NS5B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 65648.71 |
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| Organism: | Hepatitis C virus genotype 1b (isolate BK) (HCV) |
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| Description: | aa 2420-3010 |
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| Residue: | 591 |
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| Sequence: | SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQKKVTFDRLQVL
DDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIH
SVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS
TLPQVVMGSSYGFQYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIY
QCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAS
AACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLW
ARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPG
EINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIP
AASRLDLSGWFVAGYSGGDIYHSLSRARPRWFMLCLLLLSVGVGIYLLPNR
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| BDBM249180 |
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| n/a |
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| Name | BDBM249180 |
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| Synonyms: | US9457039, 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H14N8O3 |
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| Mol. Mass. | 306.2807 |
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| SMILES | C[C@@]1(N=[N+]=[N-])[C@H](O)[C@@H](CO)O[C@H]1c1cnc2c(N)ncnn12 |r| |
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| Structure | 
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