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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM250418 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | HTRF Assay | ||
| pH | 6±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 0.3±n/a nM | ||
| Comments | extracted | ||
| Citation |  Ahn, SK; Auh, J; Choi, NS; Han, CK; Kim, T; Pae, K; Shin, YJ; Han, D; Han, CK Compound having ability to inhibit 11Beta-HSD1 enzyme or pharmaceutically acceptable salt thereof, method for producing same, and pharmaceutical composition containing same as active ingredient US Patent US9464044 Publication Date 10/11/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32409.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28845 | ||
| Residue: | 292 | ||
| Sequence: |
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| BDBM250418 | |||
| n/a | |||
| Name | BDBM250418 | ||
| Synonyms: | US9464044, 8 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H27ClFN3O4S | ||
| Mol. Mass. | 483.984 | ||
| SMILES | NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cccc(Cl)c4F)CC1)C(C3)C2 |r,wU:9.10,TLB:10:9:30:3.4.31,8:3:30:9.7.6,1:3:9:30.5.6,THB:8:7:30:3.4.31,4:3:9:30.5.6,4:5:9:3.8.31,(9.29,-.66,;8.2,-1.75,;8.6,-3.23,;6.71,-1.35,;5.81,-3.27,;4.61,-2.6,;4.63,-.2,;5.38,.96,;6.71,.19,;4.05,.19,;2.72,.96,;1.38,.19,;1.38,-1.35,;.05,.96,;-1.29,.19,;-2.62,.96,;-3.95,.19,;-4.72,-1.14,;-3.18,-1.14,;-5.29,.96,;-5.29,2.5,;-6.62,3.27,;-7.95,2.5,;-7.95,.96,;-9.29,.19,;-6.62,.19,;-6.62,-1.35,;.82,2.3,;-.72,2.3,;4.05,-1.35,;3.22,-3.25,;5.38,-2.12,)| | ||
| Structure | 
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