Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM250432 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | HTRF Assay | ||
pH | 6±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 0.02±n/a nM | ||
Comments | extracted | ||
Citation | Ahn, SK; Auh, J; Choi, NS; Han, CK; Kim, T; Pae, K; Shin, YJ; Han, D; Han, CK Compound having ability to inhibit 11Beta-HSD1 enzyme or pharmaceutically acceptable salt thereof, method for producing same, and pharmaceutical composition containing same as active ingredient US Patent US9464044 Publication Date 10/11/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM250432 | |||
n/a | |||
Name | BDBM250432 | ||
Synonyms: | US9464044, 22 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H30FN3O4S | ||
Mol. Mass. | 463.565 | ||
SMILES | CN(CC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1ccccc1F |r,wU:9.9,TLB:8:9:13:16.17.15,18:16:13:9.10.11,19:16:9:13.12.11,THB:18:10:13:16.17.15,17:16:9:13.12.11,17:12:9:16.18.15,(-3.29,2.5,;-3.29,.96,;-1.95,.19,;-.62,.96,;.15,2.3,;-1.39,2.3,;.72,.19,;.72,-1.35,;2.05,.96,;3.38,.19,;4.72,.96,;3.96,-.2,;3.94,-2.6,;2.55,-3.25,;3.38,-1.35,;4.72,-2.12,;6.04,-1.35,;5.15,-3.27,;6.04,.19,;7.53,-1.75,;8.62,-.66,;7.93,-3.23,;-4.62,.19,;-5.39,-1.14,;-3.85,-1.14,;-5.95,.96,;-5.95,2.5,;-7.29,3.27,;-8.62,2.5,;-8.62,.96,;-7.29,.19,;-7.29,-1.35,)| | ||
Structure |