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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM250469 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | HTRF Assay | ||
| pH | 6±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 75.7±n/a nM | ||
| Comments | extracted | ||
| Citation |  Ahn, SK; Auh, J; Choi, NS; Han, CK; Kim, T; Pae, K; Shin, YJ; Han, D; Han, CK Compound having ability to inhibit 11Beta-HSD1 enzyme or pharmaceutically acceptable salt thereof, method for producing same, and pharmaceutical composition containing same as active ingredient US Patent US9464044 Publication Date 10/11/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32409.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28845 | ||
| Residue: | 292 | ||
| Sequence: |
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| BDBM250469 | |||
| n/a | |||
| Name | BDBM250469 | ||
| Synonyms: | US9464044, 94 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H26FN3O4S | ||
| Mol. Mass. | 471.544 | ||
| SMILES | NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccc(F)cc4)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:31:4.32.3,8:3:31:9.7.6,THB:8:7:31:4.32.3,4:5:9:8.32.3,4:3:9:31.5.6,1:3:31:9.7.6,(10,-1.15,;8.67,-1.93,;8.67,-3.47,;7.33,-1.15,;6.44,-3.08,;5.23,-2.41,;5.25,-.01,;6,1.15,;7.33,.38,;4.67,.38,;3.34,1.15,;2,.38,;2,-1.15,;.67,1.15,;.67,2.69,;-.66,3.47,;-2,2.69,;-2,1.15,;-3.33,.38,;-4.66,1.15,;-5.75,2.24,;-3.58,2.24,;-6,.38,;-7.33,1.15,;-8.67,.38,;-8.67,-1.15,;-10,-1.93,;-7.33,-1.93,;-6,-1.15,;-.66,.38,;4.67,-1.15,;3.69,-2.41,;6,-1.93,)| | ||
| Structure | 
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