| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein kinase C alpha type |
|---|
| Ligand | BDBM251540 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Inhibition Activity Assay |
|---|
| pH | 7.4±n/a |
|---|
| IC50 | 0.16±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Visser, MS; Luzzio, MJ; Papillon, J Protein kinase C inhibitors and methods of their use US Patent US9452998 Publication Date 9/27/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein kinase C alpha type |
|---|
| Name: | Protein kinase C alpha type |
|---|
| Synonyms: | KPCA_HUMAN | PKC alpha | PKC alpha and beta-2 | PKC-A | PKC-alpha | PKCA | PRKACA | PRKCA | Protein Kinase C- alpha | Protein kinase C alpha | Protein kinase C alpha (PKCa) | Protein kinase C alpha type (PKC-A) | Protein kinase C alpha type (PRKCA) | Proto-oncogene c-RAF | RAF proto-oncogene serine/threonine-protein kinase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 76755.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
|---|
| Residue: | 672 |
|---|
| Sequence: | MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV
|
|
|
|---|
| BDBM251540 |
|---|
| n/a |
|---|
| Name | BDBM251540 |
|---|
| Synonyms: | US9452998, 89 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H27F3N8O3 |
|---|
| Mol. Mass. | 532.5182 |
|---|
| SMILES | CCOCC1(N)CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1ncccc1OC(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
