| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 2 |
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| Ligand | BDBM252799 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | [35S]GTPgammaS Binding Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 3.8±n/a nM |
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| Comments | extracted |
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| Citation |  Takaishi, M; Sato, N; Shibuguchi, T; Motoki, T; Takahashi, Y; Sasaki, T; Braunton, A Tetrahydroimidazo(1,5-D)[1,4]oxazepine derivative US Patent US9458176 Publication Date 10/4/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 2 |
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| Name: | Metabotropic glutamate receptor 2 |
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| Synonyms: | GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 95584.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14416 |
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| Residue: | 872 |
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| Sequence: | MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
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| BDBM252799 |
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| n/a |
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| Name | BDBM252799 |
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| Synonyms: | US9458176, 196 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18F4N4O2 |
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| Mol. Mass. | 446.3975 |
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| SMILES | Cc1cc(ccn1)-c1nc(-c2ccc(OC(F)(F)F)c(c2)C#N)n2C[C@@H](CF)OCCc12 |r| |
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| Structure | 
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