Reaction Details | |||
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Target | Tyrosine-protein kinase JAK1 | ||
Ligand | BDBM254986 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzyme Assay | ||
IC50 | 2.2±n/a nM | ||
Citation | Takahashi, K; Watanabe, T; Hayashi, K; Kurihara, K; Nakamura, T; Yamamoto, A; Nishimura, T; Kamiyama, T; Hidaka, Y Tricyclic pyrrolopyridine compound, and JAK inhibitor US Patent US9475813 Publication Date 10/25/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK1 | |||
Name: | Tyrosine-protein kinase JAK1 | ||
Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
Type: | Protein | ||
Mol. Mass.: | 133293.73 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P23458 | ||
Residue: | 1154 | ||
Sequence: |
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BDBM254986 | |||
n/a | |||
Name | BDBM254986 | ||
Synonyms: | US9475813, 42 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H23F3N6O | ||
Mol. Mass. | 420.4314 | ||
SMILES | FC(F)(F)CNC[C@H]1CC[C@@H](CC1)N1CN(CC#N)C(=O)c2cnc3[nH]ccc3c12 |r,wU:10.13,wD:7.6,(7.34,-.28,;6,.49,;5.23,-.85,;6.77,1.82,;4.67,1.26,;4.67,2.8,;3.33,3.57,;2,2.8,;.67,3.57,;-.67,2.8,;-.67,1.26,;.67,.49,;2,1.26,;-2,.49,;-3.33,1.26,;-4.67,.49,;-6,1.26,;-7.34,.49,;-8.67,-.28,;-4.67,-1.05,;-6,-1.82,;-3.33,-1.82,;-3.33,-3.36,;-2,-4.13,;-.67,-3.36,;.8,-3.84,;1.7,-2.59,;.8,-1.35,;-.67,-1.82,;-2,-1.05,)| | ||
Structure |