Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM254993 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Assay | ||
| IC50 | 3.4±n/a nM | ||
| Citation |  Takahashi, K; Watanabe, T; Hayashi, K; Kurihara, K; Nakamura, T; Yamamoto, A; Nishimura, T; Kamiyama, T; Hidaka, Y Tricyclic pyrrolopyridine compound, and JAK inhibitor US Patent US9475813 Publication Date 10/25/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
| ||
| BDBM254993 | |||
| n/a | |||
| Name | BDBM254993 | ||
| Synonyms: | US9475813, 49 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H27N5O3S | ||
| Mol. Mass. | 405.514 | ||
| SMILES | CCN1CN([C@H]2CC[C@H](CNS(C)(=O)=O)CC2)c2c(cnc3[nH]ccc23)C1=O |r,wU:5.4,wD:8.8,(-7.34,.1,;-6,.87,;-4.67,.1,;-3.33,.87,;-2,.1,;-.67,.87,;-.67,2.41,;.67,3.18,;2,2.41,;3.33,3.18,;4.67,2.41,;6,3.18,;7.34,2.41,;5.23,4.52,;6.77,4.52,;2,.87,;.67,.1,;-2,-1.44,;-3.33,-2.21,;-3.33,-3.75,;-2,-4.52,;-.67,-3.75,;.8,-4.22,;1.7,-2.98,;.8,-1.73,;-.67,-2.21,;-4.67,-1.44,;-6,-2.21,)| | ||
| Structure | 
| ||