| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM255476 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| IC50 | 11±0.0 nM |
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| Citation |  Fyfe, MC Kinase inhibitor US Patent US9499486 Publication Date 11/22/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM255476 |
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| n/a |
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| Name | BDBM255476 |
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| Synonyms: | US10125100, Example 1 | US10392346, Example 1 | US10941115, Example 1 | US9499486, 1 | US9751837, Example 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H37N5O8S |
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| Mol. Mass. | 699.773 |
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| SMILES | COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)ccc1C(O)=O |
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| Structure | 
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