| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 72 kDa type IV collagenase |
|---|
| Ligand | BDBM256131 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Activity Assay |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 54000±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Ferdinandy, P; Csont, TB; Csonka, C; Kedvesné Kupai, K; Kovács, L; Kis-Tamás, A; Takács, FT; Kónya, D; Medgyes, G; Cseh, S; Hajdú, I; Lörincz, Z; Dormán, G; Görbe, A Inhibitors of matrix metalloproteinases US Patent US9487462 Publication Date 11/8/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 72 kDa type IV collagenase |
|---|
| Name: | 72 kDa type IV collagenase |
|---|
| Synonyms: | 72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 73870.36 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08253 |
|---|
| Residue: | 660 |
|---|
| Sequence: | MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT
SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ
IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY
WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP
GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
|
|
|
|---|
| BDBM256131 |
|---|
| n/a |
|---|
| Name | BDBM256131 |
|---|
| Synonyms: | US9487462, 13 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H23N3O3S |
|---|
| Mol. Mass. | 445.533 |
|---|
| SMILES | OC(=O)c1csc(CN(Cc2ccncc2)Cc2ccc(OCc3ccccc3)cc2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
