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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Peptidyl-prolyl cis-trans isomerase FKBP1A | ||
| Ligand | BDBM257524 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | PPlase Assay | ||
| Ki | 7.7±0.74 nM | ||
| Citation |  Gregory, MA; Kendrew, SG; Moss, SJ; Wilkinson, B Rapamycin analogues and their pharmaceutical use US Patent US9505773 Publication Date 11/29/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Peptidyl-prolyl cis-trans isomerase FKBP1A | |||
| Name: | Peptidyl-prolyl cis-trans isomerase FKBP1A | ||
| Synonyms: | 12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B | ||
| Type: | Isomerase | ||
| Mol. Mass.: | 11953.09 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P62942 | ||
| Residue: | 108 | ||
| Sequence: |
| ||
| BDBM257524 | |||
| n/a | |||
| Name | BDBM257524 | ||
| Synonyms: | US9505773, 19 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C45H69NO10 | ||
| Mol. Mass. | 784.0301 | ||
| SMILES | C[C@H](C[C@H]1CC[C@H](O)CC1)[C@@H]1C\C=C(C)\[C@@H](O)CC(=O)[C@@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@@H](O)C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 |r,wU:52.54,40.41,38.39,6.6,20.21,15.16,wD:35.43,23.24,3.2,1.0,10.58,32.33,c:13,30,t:26,28,(-4.82,-16.51,;-3.33,-16.91,;-3.33,-15.37,;-2,-14.6,;-.67,-15.37,;.67,-14.6,;.67,-13.06,;2,-12.29,;-.67,-12.29,;-2,-13.06,;-2,-17.68,;-.67,-16.91,;6,-17.68,;6,-19.22,;4.67,-19.99,;7.34,-19.99,;8.67,-19.22,;7.34,-21.53,;8.67,-22.3,;10,-21.53,;8.67,-23.84,;7.18,-24.24,;8.05,-26.15,;6,-26.92,;6,-28.46,;4.67,-26.15,;3.33,-26.92,;2,-26.15,;.67,-26.92,;-.67,-26.15,;-2,-26.92,;-2,-28.46,;-3.33,-26.15,;-3.33,-24.61,;-4.67,-26.92,;-6,-26.15,;-7.34,-26.92,;-8.67,-26.15,;-8.67,-24.61,;-10,-23.84,;-7.34,-23.84,;-8.67,-23.07,;-6,-24.61,;-7.34,-22.3,;-8.67,-21.53,;-6,-21.53,;-4.67,-22.3,;-6,-19.99,;-7.34,-19.22,;-7.34,-17.68,;-6,-16.91,;-4.67,-17.68,;-4.67,-19.22,;-3.33,-19.99,;-3.33,-21.53,;-2,-19.22,)| | ||
| Structure | 
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