Reaction Details |
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Target | Orexin receptor type 2 |
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Ligand | BDBM294334 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FLIPR Ca2+ Flux Assay |
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IC50 | 33.8±n/a nM |
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Citation | Kuduk, SD; Skudlarek, JW 2-pyridyloxy-3-ester-4-nitrile orexin receptor antagonists US Patent US9586950 Publication Date 3/7/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin receptor type 2 |
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Name: | Orexin receptor type 2 |
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
Type: | Protein |
Mol. Mass.: | 50710.53 |
Organism: | Homo sapiens (Human) |
Description: | O43614 |
Residue: | 444 |
Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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BDBM294334 |
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n/a |
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Name | BDBM294334 |
Synonyms: | US9586950, 3 | methyl 4-cyano-2-{[(3R,6R)-1-{[6- methoxy-2-(2H-1,2,3-triazol-2- yl)pyridin-3-yl]carbonyl}-6- methylpiperidin-3-yl]oxy}pyridine- 3-carboxylate |
Type | Small organic molecule |
Emp. Form. | C23H23N7O5 |
Mol. Mass. | 477.4726 |
SMILES | COC(=O)c1c(O[C@@H]2CC[C@@H](C)N(C2)C(=O)c2ccc(OC)nc2-n2nccn2)nccc1C#N |
Structure |
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