| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
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| Ligand | BDBM294339 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FLIPR Ca2+ Flux Assay |
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| IC50 | 432±n/a nM |
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| Citation |  Kuduk, SD; Skudlarek, JW 2-pyridyloxy-3-ester-4-nitrile orexin receptor antagonists US Patent US9586950 Publication Date 3/7/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin/Hypocretin receptor type 1 |
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| Name: | Orexin/Hypocretin receptor type 1 |
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| Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
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| Type: | Protein |
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| Mol. Mass.: | 47554.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43613 |
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| Residue: | 425 |
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| Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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| BDBM294339 |
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| n/a |
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| Name | BDBM294339 |
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| Synonyms: | US9586950, 7 | methyl 4-cyano-2-{[(3R,6R)-1-{[2- fluoro-6-(2H-1,2,3-triazol-2- yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]oxy}pyridine- 3-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21FN6O4 |
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| Mol. Mass. | 464.449 |
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| SMILES | COC(=O)c1c(O[C@@H]2CC[C@@H](C)N(C2)C(=O)c2c(F)cccc2-n2nccn2)nccc1C#N |
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| Structure | 
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