| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM260406 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Glucokinase Activity Assay |
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| EC50 | 413.2±n/a nM |
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| Citation |  Lin, S; Parmee, ER; Xu, J 2-pyridinecarboxamide derivatives, compositions containing such compounds, and methods of treatment US Patent US9527838 Publication Date 12/27/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | FLAG-Glucokinase (GK) |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | FLAG-tagged fusion protein |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 1009.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 8 |
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| Sequence: | |
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| Component 2 |
| Name: | Hexokinase-4 |
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| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
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| Type: | Enzyme |
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| Mol. Mass.: | 52175.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35557 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| BDBM260406 |
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| n/a |
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| Name | BDBM260406 |
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| Synonyms: | US9527838, 34 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H15FN4O3S3 |
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| Mol. Mass. | 498.573 |
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| SMILES | OC(=O)Cc1csc(NC(=O)c2nc(Sc3ccccn3)ccc2Sc2ccc(F)cc2)n1 |
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| Structure | 
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