| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-A1/Cyclin-dependent kinase 2 |
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| Ligand | BDBM253928 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Caliper Assay |
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| IC50 | 1670±n/a nM |
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| Citation |  Strum, JC; Bisi, JE; Roberts, PJ; Tavares, FX HSPC-sparing treatments for RB-positive abnormal cellular proliferation US Patent US9527857 Publication Date 12/27/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-A1/Cyclin-dependent kinase 2 |
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| Name: | Cyclin-A1/Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2/CycA | CDK2/Cyclin A1 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1979627 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| Component 2 |
| Name: | Cyclin-A1 |
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| Synonyms: | CCNA1 | CCNA1_HUMAN | CDK2/Cyclin A1 | Cyclin-A1 | Cyclin-A1/Cyclin-dependent kinase 4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 52343.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P78396 |
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| Residue: | 465 |
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| Sequence: | METGFPAIMYPGSFIGGWGEEYLSWEGPGLPDFVFQQQPVESEAMHCSNPKSGVVLATVA
RGPDACQILTRAPLGQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKK
ALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFN
TVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDIT
EGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKY
EEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVR
TENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIV
PCLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLLQ
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| BDBM253928 |
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| n/a |
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| Name | BDBM253928 |
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| Synonyms: | US10189849, Compound 27 | US10927120, Compound 27 | US9464092, T | US9527857, T | US9957276, Compound 27 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30N8O |
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| Mol. Mass. | 446.548 |
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| SMILES | CN1CCN(CC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1 |
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| Structure | 
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