| Reaction Details |
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 | Report a problem with these data |
| Target | Rho-associated protein kinase 1 |
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| Ligand | BDBM163433 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescent Polarization Assay |
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| Temperature | 296.15±n/a K |
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| IC50 | 21000±0 nM |
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| Comments | extracted |
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| Citation |  McKerracher, L; Bond, LM Treatment of cerebral cavernous malformations and cerebral aneurysms with Rho kinase inhibitors US Patent US9687483 Publication Date 6/27/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Rho-associated protein kinase 1 |
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| Name: | Rho-associated protein kinase 1 |
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| Synonyms: | Liver regenerat ion-related protein LRRG199 | Liver regeneration-related protein LRRG199 | ROCK1_RAT | Rho-associated protein kinase 1 | Rho-associated protein kinase 1 (ROCK I) | Rho-associated, coiled-coil-containing protein kinase 1 | Rho-kinase (ROCK I) | Rock1 | p150 RhoA-binding kinase ROK beta | p160 ROCK-1 |
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| Type: | Protein |
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| Mol. Mass.: | 159610.34 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q63644 |
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| Residue: | 1369 |
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| Sequence: | MSTGDSFETRFEKIDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTYYSNRRYLPSANPSENRSSSNV
DKNVQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESA
VSQIEKEKMLLQHRINEYQRKVEQENEKRRNVENEVSTLKDQLEDLRKASQSSQLANEKL
TQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSVSQLESLNRELQERNRMLENSKSQAD
KDYYQLQAVLEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLERVEGERKEAQDMLN
HSEKEKNNLEIDLNYKLKSIQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKL
KEEREAREKAENRVVETEKQCSMLDVDLKQSQQKLEHLTENKERLEDAVKSLTLQLEQES
NKRILLQSELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMR
ELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLRKIQELQSEKETLSTQLDLAETKAE
SEQLARGILEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANNALTKDIELLRKENE
ELNERMRTAEEEYKLKKEEEISNLKAAFEKNISTERTLKTQAVNKLAEIMNRKDFKIDRK
KANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECTHRNELQMQL
ASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPVGSACIPYLFIFYSSSSRIEGWL
SVPNRGNIKRYGWKKQYVVVSSKKMLFYNDEQDKEQSSPSMVLDIDKLFHVRPVTQGDVY
RAETEEIPKIFQILYANEGECRKDIEVEPVQQGEKTNFQNHKGHEFIPTLYHFPANCEAC
AKPLWHVFKPPPALECRRCHVKSHRDHLDKKEDLIPPCKVSYDVTSARDMLLLACPQDEQ
KKWVTHLVKKIPKKAPSGFVRASPRTLSTRSTANQSFRKVVKNTSGKTS
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|
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| BDBM163433 |
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| n/a |
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| Name | BDBM163433 |
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| Synonyms: | BA-1049 | US11198680, Compound BA 1049 (R) | US9687483, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H21N3O2S |
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| Mol. Mass. | 319.422 |
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| SMILES | C[C@@H](N)C1CCN(CC1)S(=O)(=O)c1cccc2cnccc12 |r| |
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| Structure | 
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