| Reaction Details |
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 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E] |
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| Ligand | BDBM410348 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assays |
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| IC50 | 0.013±n/a nM |
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| Citation |  Aversa, RJ; Burger, MT; Dillon, MP; Dineen, Jr., TA; Karki, R; Ramurthy, S; Rauniyar, V; Robinson, R; Sarver, PJ Tricyclic compounds and compositions as kinase inhibitors US Patent US10377770 Publication Date 8/13/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| RAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E] |
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| Name: | RAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E] |
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| Synonyms: | C-RAF | Proto-oncogene C-Raf (C-Raf FL) | RAF | RAF proto-oncogene serine/threonine-protein kinase | RAF1 | RAF1_HUMAN |
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| Type: | n/a |
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| Mol. Mass.: | 73012.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04049[Y340E,Y341E] |
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| Residue: | 648 |
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| Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSEEWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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| BDBM410348 |
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| n/a |
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| Name | BDBM410348 |
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| Synonyms: | US10377770, Example 108 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26F2N4O3 |
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| Mol. Mass. | 480.5064 |
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| SMILES | Cc1ccc(NC(=O)c2ccnc(c2)C(C)(F)F)cc1-c1cnc2[C@H](O)C[C@@H]3COCCN3c2c1 |r| |
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| Structure | 
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