Reaction Details |
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Target | Metalloproteinase inhibitor 2 |
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Ligand | BDBM413580 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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IC50 | 21.0±n/a nM |
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Citation | Prades Cosano, R; Seco Moral, J; Tarragó Clua, MT Gelatinase inhibitors and use thereof US Patent US10414797 Publication Date 9/17/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Metalloproteinase inhibitor 2 |
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Name: | Metalloproteinase inhibitor 2 |
Synonyms: | Metalloproteinase inhibitor 2 (TIMP2) | TIMP-2 | TIMP2 | TIMP2_CRILO | Tissue inhibitor of metalloproteinases 2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 21943.02 |
Organism: | Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster) |
Description: | Q60453 |
Residue: | 196 |
Sequence: | RACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIKQIKMFKGPDK
DIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHITLCDFIVPWDTLSTTQKKSL
NHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTEKSINGHQAKFFACIKRSDGSCAWY
RGAAPPKQEFLDIEDP
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BDBM413580 |
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n/a |
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Name | BDBM413580 |
Synonyms: | (2 S)-1-[(2S)-2-[acetyl(methyl)amino]propanoyl]-N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl)amino]-1-(hydroxycarbamoyl)propyl]carbamoyl]-2-methyl-butyl]-N-methyl-pyrrolidine-2-carboxamide | US10414797, Example 12 |
Type | Small organic molecule |
Emp. Form. | C29H42F2N6O7 |
Mol. Mass. | 624.6766 |
SMILES | CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](C)N(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO |r| |
Structure |
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