| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 2 |
|---|
| Ligand | BDBM413923 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Reporter Displacement Assay |
|---|
| Kd | >5000±n/a nM |
|---|
| Citation |  Jefson, MR; Lowe, III, JA; Dey, F; Bergmann, A; Schoop, A Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase US Patent US10421756 Publication Date 9/24/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 2 |
|---|
| Name: | Histone deacetylase 2 |
|---|
| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
|---|
| Type: | Chromatin regulator; hydrolase; repressor |
|---|
| Mol. Mass.: | 55356.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q92769 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
|
|
|
|---|
| BDBM413923 |
|---|
| n/a |
|---|
| Name | BDBM413923 |
|---|
| Synonyms: | US10421756, Compound 107 | US10421756, Compound 109 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H23N5O2 |
|---|
| Mol. Mass. | 365.4289 |
|---|
| SMILES | CC(=O)N1C2CCC1CN(C2)C(=O)Nc1cc(ccc1N)-c1ccncc1 |TLB:1:3:5.6:9.10.8| |
|---|
| Structure | 
|
|---|
Search and Browse
