| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phosphatidylinositol 3-kinase regulatory subunit alpha |
|---|
| Ligand | BDBM414902 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TBD |
|---|
| Ki | <0.020±n/a nM |
|---|
| Citation |  Braun, M; Garland, K; Hanan, E; Purkey, H; Staben, ST; Heald, RA; Knight, J; Macleod, C; Lu, A; Wu, G; Yeap, SK Tricyclic PI3K inhibitor compounds and methods of use US Patent US10435414 Publication Date 10/8/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phosphatidylinositol 3-kinase regulatory subunit alpha |
|---|
| Name: | Phosphatidylinositol 3-kinase regulatory subunit alpha |
|---|
| Synonyms: | GRB1 | P85A_HUMAN | PI3-kinase class I | PI3-kinase p85 subunit alpha | PI3-kinase p85-alpha subunit | PI3-kinase p85-subunit alpha | PI3-kinase subunit p85-alpha | PI3K | PIK3CG/PIK3R1 | PIK3R1 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha (PI3K alpha) | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3K p85-alpha) | Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) | Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3RI) | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 (PI3 Kinase alpha) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3Kalpha p85alpha) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3Kalpha) | Phosphoinositide 3-Kinase (PI3K) Chain B | PtdIns-3-kinase p85-alpha | p84 alpha | p85 alpha |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 83592.82 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P27986 |
|---|
| Residue: | 724 |
|---|
| Sequence: | MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH
VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
|
|
|
|---|
| BDBM414902 |
|---|
| n/a |
|---|
| Name | BDBM414902 |
|---|
| Synonyms: | (S)-2-((1-(2- aminobenzo [d]oxazol-5- yl)-7,8,9,10- tetrahydro- 6-oxa-2,10a- diazacyclo- octa[cd] inden-4-yl) amino)-2- cyclopropyl- acetamide | US10435414, Compound 171 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H24N6O3 |
|---|
| Mol. Mass. | 432.4751 |
|---|
| SMILES | NC(=O)[C@@H](Nc1cc2OCCCCn3c(nc(c1)c23)-c1ccc2oc(N)nc2c1)C1CC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
