Reaction Details |
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Target | Guanylate cyclase soluble subunit alpha-1/beta-1 |
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Ligand | BDBM280795 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Binding Assay |
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Ki | 0.022±n/a nM |
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Citation | Berger, R; Chen, Y; Li, G; Garfunkle, J; Li, H; Miao, S; Raghavan, S; Smith, CJ; Stelmach, J; Whitehead, A; Zhang, R; Zhang, Y; Fu, J; Ji, G; Jiang, F Soluble guanylate cyclase stimulators US Patent US10428076 Publication Date 10/1/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Guanylate cyclase soluble subunit alpha-1/beta-1 |
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Name: | Guanylate cyclase soluble subunit alpha-1/beta-1 |
Synonyms: | Soluble Guanylate Cyclases | Soluble guanylate cyclase (sGC) | Soluble guanylate cyclase alpha 1 and beta 1 subunits (sGC) | Soluble guanylate cyclase alpha1/beta1 complex | soluble guanylate cyclase activators | soluble guanylate cyclase apha 1 and soluble guanylate cyclase beta 1 |
Type: | Enzyme |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Guanylate cyclase soluble subunit alpha-1 |
Synonyms: | GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC) |
Type: | Enzyme |
Mol. Mass.: | 77457.21 |
Organism: | Homo sapiens (Human) |
Description: | Q02108 |
Residue: | 690 |
Sequence: | MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
QQGTNSKPCFQKKDVEDGNANFLGKASGID
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Component 2 |
Name: | Guanylate cyclase soluble subunit beta-1 |
Synonyms: | GCYB1_HUMAN | GUC1B3 | GUCSB3 | GUCY1B1 | GUCY1B3 | Guanylate cyclase soluble (GCS-beta-1) | Solube guanylate cyclase beta-1 (sGCβ1) | soluble guanylate cyclase beta-1 (sGC) |
Type: | Enzyme |
Mol. Mass.: | 70496.05 |
Organism: | Homo sapiens (Human) |
Description: | Q02153 |
Residue: | 619 |
Sequence: | MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV
TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
VWFLSRKNTGTEETKQDDD
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BDBM280795 |
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n/a |
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Name | BDBM280795 |
Synonyms: | (S)-3-(2-{4-amino-2-[6- fluoro-1-(2-fluorobenzyl)- 1H-indazol-3-yl]-5-methyl-6- oxo-6,7-dihydro-5H- pyrrolo[2,3-d]pyrimidin-5- yl}-1,3-thiazol-4-yl)-2,2- dimethylpropanoic acid | US10030027, Example 62A | US10428076, Example 62A |
Type | Small organic molecule |
Emp. Form. | C29H25F2N7O3S |
Mol. Mass. | 589.616 |
SMILES | CC(C)(Cc1csc(n1)[C@]1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(F)ccc12)C(O)=O |r| |
Structure |
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