Ki Summary

Reaction Details

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Target

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824]

Ligand

BDBM355961

Substrate/Competitor

n/a

Meas. Tech.

Biochemical Assay

IC50

0.005±n/a nM

Citation

Soldermann, CP; Quancard, J; Schlapbach, A; Simic, O; Tintelnot-Blomley, M; Zoller, T Pyrazolo pyrimidine derivatives and their use as MALT1 inhbitors US Patent US10442808 Publication Date 10/15/2019

More Info.:

Get all data from this article, Assay Method

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824]

Name:

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824]

Synonyms:

MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)(aa 329-824)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

55563.19

Organism:

Homo sapiens (Human)

Description:

amino acids 329-824

Residue:

495

Sequence:

NKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEY
EMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLM
QEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANG
IFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEY
SAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCD
AYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLS
YQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGH
YHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTD
EIPFSFSDRLRISEK

BDBM355961

n/a

Name

BDBM355961

Synonyms:

1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-yl)-3-(2- chloro-7-((S)-1-((R)- 2- methoxypropoxy)eth- yl)pyrazolo[1,5- a]pyrimidin-6-yl)urea | US10442808, Example 85 | US9815842, Example 85

Type

Small organic molecule

Emp. Form.

C20H21Cl2N9O3

Mol. Mass.

506.345

SMILES

CO[C@H](C)CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12 |r|

Structure