| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 3-kinase regulatory subunit beta |
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| Ligand | BDBM295665 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | p110alpha (Alpha) PI3K Binding Assay |
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| Ki | 99.7±n/a nM |
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| Citation |  Braun, M; Hanan, E; Staben, ST; Heald, RA; MacLeod, C; Elliott, R Benzoxazepin oxazolidinone compounds and methods of use US Patent US10112932 Publication Date 10/30/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 3-kinase regulatory subunit beta |
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| Name: | Phosphatidylinositol 3-kinase regulatory subunit beta |
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| Synonyms: | P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 81542.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00459 |
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| Residue: | 728 |
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| Sequence: | MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLA
LPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALG
PAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPP
ALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSK
IQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTR
LLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTA
IEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRT
KLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNE
TEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVV
VDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPG
PGPPPAAR
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| BDBM295665 |
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| n/a |
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| Name | BDBM295665 |
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| Synonyms: | (S)-2-((2-((S)-4-(difluoromethyl)- 2-oxooxazolidin-3-yl)-5,6- dihydrobenzo[f]imidazo[1,2- d][1,4]oxazepin-9- yl)amino)propanamide | US10112932, Compound 101 | US10851091, Compound 101 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19F2N5O4 |
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| Mol. Mass. | 407.3714 |
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| SMILES | C[C@H](Nc1ccc2-c3nc(cn3CCOc2c1)N1[C@@H](COC1=O)C(F)F)C(N)=O |r| |
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| Structure | 
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