| Reaction Details |
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 | Report a problem with these data |
| Target | Catenin beta-1/Protein Wnt-3a |
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| Ligand | BDBM418346 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Evaluation of Biological Activity |
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| EC50 | 42.0±n/a nM |
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| Citation |  KC, SK; Wallace, DM; Hood, J; Barroga, CF γ-diketones as Wnt/β-catenin signaling pathway activators US Patent US10457672 Publication Date 10/29/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Catenin beta-1/Protein Wnt-3a |
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| Name: | Catenin beta-1/Protein Wnt-3a |
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| Synonyms: | Wnt/beta-Catenin |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Protein Wnt-3a |
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| Synonyms: | WNT3A | WNT3A_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39379.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1469237 |
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| Residue: | 352 |
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| Sequence: | MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYV
EIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGV
AFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDAR
SAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASE
MVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVS
SHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
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| Component 2 |
| Name: | Catenin beta-1 |
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| Synonyms: | CTNB1_HUMAN | CTNNB | CTNNB1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 85484.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1504364 |
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| Residue: | 781 |
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| Sequence: | MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT
NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK
KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL
VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC
LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA
GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA
AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM
AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL
VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV
QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFH
SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD
L
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| BDBM418346 |
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| n/a |
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| Name | BDBM418346 |
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| Synonyms: | US10457672, Compound 261 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15NO2 |
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| Mol. Mass. | 277.3172 |
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| SMILES | O=C(CCC(=O)c1ccc2[nH]ccc2c1)c1ccccc1 |
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| Structure | 
|
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