| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 7 |
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| Ligand | BDBM50440284 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TLR7 Agonist Activity Assay |
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| EC50 | 100±n/a nM |
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| Citation |  Young, IS; Gangwar, S; Posy, SL; Poudel, YB; Sivaprakasam, P Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor US Patent US10457681 Publication Date 10/29/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 7 |
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| Name: | Toll-like receptor 7 |
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| Synonyms: | ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7) |
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| Type: | Enzyme |
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| Mol. Mass.: | 120945.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NYK1 |
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| Residue: | 1049 |
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| Sequence: | MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV
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| BDBM50440284 |
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| n/a |
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| Name | BDBM50440284 |
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| Synonyms: | CHEMBL2424780 | US10457681, Compound Vesatolimod | US10487084, Compound Vesatolimod | US10508115, Compound Vesatolimod | US10654856, GS-9620 | US10919895, Vesatolimod | US10981914, Compound Vesatolimod | US11242345, Example GS-9620 | US9708325, GS-9620 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H30N6O2 |
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| Mol. Mass. | 410.5126 |
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| SMILES | CCCCOc1nc(N)c2NC(=O)CN(Cc3cccc(CN4CCCC4)c3)c2n1 |
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| Structure | 
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