Reaction Details |
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Target | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] |
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Ligand | BDBM420250 |
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Substrate/Competitor | n/a |
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Meas. Tech. | MKNK1 Kinase High ATP Assay |
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IC50 | 1.000±n/a nM |
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Citation | Giese, A; Klar, U; Graham, K; Kettschau, G; Sülzle, D; Lienau, P; Petersen, K; LeFranc, J; Schmidt, N Pyrazolopyridinamines as MKNK1 and MKNK2 inhibitors US Patent US10487092 Publication Date 11/26/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] |
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Name: | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] |
Synonyms: | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] | MAP kinase signal-integrating kinase 1 (MNK1) (T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)(T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] | MAP kinase-interacting serine/threonine-protein kinase 1 (T344D) | MKNK1 | MKNK1 (aa 1-424) T344D | MKNK1_HUMAN | MNK1 | MNK1a |
Type: | Protein |
Mol. Mass.: | 47416.00 |
Organism: | Homo sapiens (Human) |
Description: | Q9BUB5-2 with T344D |
Residue: | 424 |
Sequence: | MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES
PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR
CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA
HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPDPQVLQRNSSTMDLTLF
AAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSP
PTAL
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BDBM420250 |
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n/a |
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Name | BDBM420250 |
Synonyms: | 1-((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-7-ylcarbonyl)azetidine-3-carbonitrile | US10487092, Example 98 |
Type | Small organic molecule |
Emp. Form. | C23H21N7O2S |
Mol. Mass. | 459.524 |
SMILES | COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC(C1)C#N |r| |
Structure |
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