Reaction Details |
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Target | Proto-oncogene Wnt-1 |
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Ligand | BDBM385219 |
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Substrate/Competitor | n/a |
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Meas. Tech. | The screening assay for Wnt activity |
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EC50 | 1536±n/a nM |
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Citation | KC, SK; Mittapalli, GK; Hofilena, BJ; Marakovits, JT; Chiruta, C; Mak, CC; Cao, J Isoquinolin-3-yl carboxamides and preparation and use thereof US Patent US10508099 Publication Date 12/17/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Proto-oncogene Wnt-1 |
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Name: | Proto-oncogene Wnt-1 |
Synonyms: | INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 41006.01 |
Organism: | Homo sapiens (human) |
Description: | P04628 |
Residue: | 370 |
Sequence: | MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPS
LQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRG
CRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLF
GREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLR
AVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCT
YSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNC
THTRVLHECL
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BDBM385219 |
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n/a |
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Name | BDBM385219 |
Synonyms: | US10287267, Compound 481 | US10508099, Compound 481 | US10556885, Compound 481 | US11174244, Compound 481 | US11673881, Compound 481 |
Type | Small organic molecule |
Emp. Form. | C18H20N6O |
Mol. Mass. | 336.391 |
SMILES | Cn1cc(nn1)-c1ccc2cnc(NC(=O)[C@@H]3CCCNC3)cc2c1 |r| |
Structure |
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