Reaction Details |
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Target | Baculoviral IAP repeat-containing protein 2 [253-363] |
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Ligand | BDBM422081 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biological Assay 1: affinity of compounds to cIAP1-BIR3, cIAP2-BIR3, XIAP-BIR3 |
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IC50 | <10.00±n/a nM |
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Citation | Sun, F; Ding, CZ; Cai, Z; Qian, W; Hu, G; Li, J; Chen, S Benzimidazole-linked indole compound acting as novel divalent IAP antagonist US Patent US10508103 Publication Date 12/17/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Baculoviral IAP repeat-containing protein 2 [253-363] |
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Name: | Baculoviral IAP repeat-containing protein 2 [253-363] |
Synonyms: | API1 | BIRC2 | BIRC2_HUMAN | Baculoviral IAP repeat-containing protein 2 | HIAP-2 | IAP homolog B | Inhibitor of apoptosis protein 2 | MIHB | RING finger protein 48 | RNF48 | TNFR2-TRAF-signaling complex protein 2 | cIAP-1 BIR3 |
Type: | BIR3 domain |
Mol. Mass.: | 12929.05 |
Organism: | Homo sapiens (Human) |
Description: | Human cIAP1 BIR3 domain (residues 253-363) was used in binding assays. |
Residue: | 111 |
Sequence: | SLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGG
LRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTS
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BDBM422081 |
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n/a |
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Name | BDBM422081 |
Synonyms: | US10508103, Embodiment 38 |
Type | Small organic molecule |
Emp. Form. | C43H58F3N9O4 |
Mol. Mass. | 821.9737 |
SMILES | CC[C@H](NC(=O)[C@H](C)NC)C(=O)N1CCC[C@H]1Cc1c([nH]c2cc(F)ccc12)-c1nc2cc(F)ccc2n1C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C |r| |
Structure |
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