| Reaction Details |
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 | Report a problem with these data |
| Target | Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] |
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| Ligand | BDBM287907 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | R132H IDH1 Enzymatic Assay |
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| IC50 | 4.00±n/a nM |
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| Citation |  Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Ellis, JM; Esposite, S; Hoffman, DM; Huang, C; Kattar, SD; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Reutershan, MH; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Wu, Z; Yu, Y; Gibeau, CR Tricyclic compounds as inhibitors of mutant IDH enzymes US Patent US10508108 Publication Date 12/17/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] |
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| Name: | Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] |
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| Synonyms: | Cytosolic NADP-isocitrate dehydrogenase (IDH1)(R132H) | IDH1 | IDH1 R132H | IDH1(R132H) | IDHC_HUMAN | Isocitrate dehydrogenase (IDH1)(R132H) | Isocitrate dehydrogenase 1 mutant (R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH)(R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (R132H) | PICD |
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| Type: | Protein |
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| Mol. Mass.: | 46641.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human IDH1 R132H (SEQ ID No. 2 in patent). First three are removed. Google patent parsed wrong. |
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| Residue: | 414 |
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| Sequence: | MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
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| BDBM287907 |
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| n/a |
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| Name | BDBM287907 |
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| Synonyms: | 3-[6-(6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-ylcarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-8-yl]-1,3-oxazolidin-2-one | US10086000, Example 124 | US10508108, Example 124 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26N4O3 |
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| Mol. Mass. | 454.5203 |
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| SMILES | O=C(C1CCc2ccccc2CC1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOC1=O |
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| Structure | 
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