| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Ligand | BDBM247220 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PDE9 Inhibition Assay |
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| IC50 | 36.0±n/a nM |
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| Citation |  Svenstrup, N; Wen, K; Wang, Y PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases US Patent US10513524 Publication Date 12/24/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A) |
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| Type: | Protein |
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| Mol. Mass.: | 68488.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O76083 |
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| Residue: | 593 |
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| Sequence: | MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
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| BDBM247220 |
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| n/a |
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| Name | BDBM247220 |
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| Synonyms: | US10513524, Compound (P2) | US9434733, 2-[[3-(3-pyridyloxy)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one | US9533992, 2-[[3-(3-pyridyloxy)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22N6O3 |
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| Mol. Mass. | 382.4164 |
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| SMILES | O=c1[nH]c(CN2CC(C2)Oc2cccnc2)nn2c(ncc12)C1CCOCC1 |
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| Structure | 
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