Reaction Details | |||
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Target | Tyrosine-protein kinase JAK3 | ||
Ligand | BDBM292111 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biochemical JAK and Off-Target Kinase Assays | ||
Ki | 0.55±n/a nM | ||
Citation | Fatheree, PR; Jacobsen, JR; Brandt, GE; Fleury, M; Jiang, L; Smith, C; Sullivan, SD; Van Orden, LJ; Beausoleil, A JAK kinase inhibitor compounds for treatment of respiratory disease US Patent US10526330 Publication Date 1/7/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK3 | |||
Name: | Tyrosine-protein kinase JAK3 | ||
Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase | ||
Type: | Protein | ||
Mol. Mass.: | 125111.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P52333 | ||
Residue: | 1124 | ||
Sequence: |
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BDBM292111 | |||
n/a | |||
Name | BDBM292111 | ||
Synonyms: | US10100049, Example 8 | US10183942, Example 8 | US10526330, Example 8 | US10913740, Example 8 | US11299492, Example 8 | US11718616, Example 8 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H33FN6O2 | ||
Mol. Mass. | 504.599 | ||
SMILES | CCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2CN(CCNC3CC(C3)OC)CCc2[nH]1 |(-11.45,-2.63,;-10.11,-1.86,;-10.11,-.32,;-11.45,.45,;-11.45,1.99,;-12.78,2.76,;-10.11,2.76,;-10.11,4.3,;-8.78,1.99,;-8.78,.45,;-7.44,-.32,;-6.11,.45,;-4.78,-.32,;-4.78,-1.86,;-3.63,-2.89,;-4.26,-4.3,;-5.79,-4.14,;-6.11,-2.63,;-7.44,-1.86,;-2.15,-2.49,;-1.24,-1.25,;.22,-1.72,;1.56,-.95,;2.89,-1.72,;4.23,-.95,;5.56,-1.72,;6.89,-.95,;8.23,-1.72,;8.62,-3.21,;10.11,-2.81,;9.71,-1.32,;11.45,-3.58,;12.78,-2.81,;2.89,-3.26,;1.56,-4.03,;.22,-3.26,;-1.24,-3.74,)| | ||
Structure |