Reaction Details |
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Target | Thyroid hormone receptor beta |
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Ligand | BDBM426634 |
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Substrate/Competitor | n/a |
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Meas. Tech. | transactivation assay |
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EC50 | 0.880±1.12 nM |
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Citation | Scanlan, T; Devereaux, J; Placzek, A; Banerji, T; Ferrara, S; Meinig, JM; Banerji, T Derivatives of sobetirome US Patent US10544075 Publication Date 1/28/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Thyroid hormone receptor beta |
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Name: | Thyroid hormone receptor beta |
Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta |
Type: | Receptor |
Mol. Mass.: | 52793.62 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. |
Residue: | 461 |
Sequence: | MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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BDBM426634 |
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n/a |
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Name | BDBM426634 |
Synonyms: | US10544075, Compound JD-20 |
Type | Small organic molecule |
Emp. Form. | C18H18Br2O4 |
Mol. Mass. | 458.141 |
SMILES | CC(C)c1cc(Cc2c(Br)cc(OCC(O)=O)cc2Br)ccc1O |
Structure |
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