| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calmodulin-domain protein kinase 1 |
|---|
| Ligand | BDBM50345741 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | luminescent kinase assay |
|---|
| IC50 | 863±n/a nM |
|---|
| Citation |  Van Voorhis, WC; Hol, WG; Larson, ET; Maly, DJ; Merritt, E; Ojo, KK Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases US Patent US10544104 Publication Date 1/28/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calmodulin-domain protein kinase 1 |
|---|
| Name: | Calmodulin-domain protein kinase 1 |
|---|
| Synonyms: | Calmodulin-domain protein kinase 1 | Calmodulin-domain protein kinase 1 (CDPK1) | Calmodulin-domain protein kinase, putative |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 57248.42 |
|---|
| Organism: | Toxoplasma gondii |
|---|
| Description: | n/a |
|---|
| Residue: | 507 |
|---|
| Sequence: | MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKG
SFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFED
KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENL
LLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVIL
YILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISAR
DALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKEL
TAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNG
YIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSV
LSEVDKNNDGEVDFDEFQQMLLKLCGN
|
|
|
|---|
| BDBM50345741 |
|---|
| n/a |
|---|
| Name | BDBM50345741 |
|---|
| Synonyms: | 1-isopropyl-3-(3-methoxynaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | CHEMBL1785022 | US10544104, Compound 7s | US11247972, Compound 7s | US9765037, Compound 7s |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H19N5O |
|---|
| Mol. Mass. | 333.3871 |
|---|
| SMILES | COc1cc2ccccc2cc1-c1nn(C(C)C)c2ncnc(N)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
