| Reaction Details |
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 | Report a problem with these data |
| Target | Calmodulin-domain protein kinase 1 |
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| Ligand | BDBM50389695 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | luminescent kinase assay |
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| IC50 | 0.800±n/a nM |
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| Citation |  Van Voorhis, WC; Hol, WG; Larson, ET; Maly, DJ; Merritt, E; Ojo, KK Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases US Patent US10544104 Publication Date 1/28/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Calmodulin-domain protein kinase 1 |
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| Name: | Calmodulin-domain protein kinase 1 |
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| Synonyms: | Calmodulin-domain protein kinase 1 | Calmodulin-domain protein kinase 1 (CDPK1) | Calmodulin-domain protein kinase, putative |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57248.42 |
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| Organism: | Toxoplasma gondii |
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| Description: | n/a |
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| Residue: | 507 |
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| Sequence: | MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKG
SFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFED
KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENL
LLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVIL
YILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISAR
DALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKEL
TAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNG
YIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSV
LSEVDKNNDGEVDFDEFQQMLLKLCGN
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| BDBM50389695 |
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| n/a |
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| Name | BDBM50389695 |
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| Synonyms: | CHEMBL2070062 | US10544104, Compound 40 | US11247972, Compound 40 | US9765037, Compound 40 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23N5O |
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| Mol. Mass. | 409.483 |
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| SMILES | CC(C)n1nc(-c2ccc3cc(OCc4ccccc4)ccc3c2)c2c(N)ncnc12 |
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| Structure | 
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