| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene Wnt-1 |
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| Ligand | BDBM293647 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | The screening assay for Wnt activity |
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| EC50 | 144±n/a nM |
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| Citation |  KC, SK; Mak, CC; Eastman, BW; Cao, J; Bollu, V; Mittapalli, GK; Chiruta, C Isoquinolin-3-yl carboxamides and preparation and use thereof US Patent US10544128 Publication Date 1/28/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene Wnt-1 |
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| Name: | Proto-oncogene Wnt-1 |
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| Synonyms: | INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41006.01 |
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| Organism: | Homo sapiens (human) |
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| Description: | P04628 |
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| Residue: | 370 |
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| Sequence: | MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPS
LQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRG
CRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLF
GREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLR
AVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCT
YSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNC
THTRVLHECL
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| BDBM293647 |
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| n/a |
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| Name | BDBM293647 |
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| Synonyms: | US10106527, Compound 445 | US10544128, Compound 445 | US11548872, Compound 445 | US20230286945, Compound 445 | US9951048, Compound 445 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N8O |
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| Mol. Mass. | 442.5162 |
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| SMILES | CN1CCN(CC1)c1cc(CC(=O)Nc2cc3cc(ccc3cn2)-c2cn(C)nn2)ccn1 |
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| Structure | 
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