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TargetGlycogen synthase kinase-3 beta
LigandBDBM293490
Substrate/Competitorn/a
Meas. Tech.The GSK3beta kinase assay
EC50 2.00±n/a nM
Citation KC, SK; Mak, CC; Eastman, BW; Cao, J; Bollu, V; Mittapalli, GK; Chiruta, C Isoquinolin-3-yl carboxamides and preparation and use thereof US Patent US10544128 Publication Date 1/28/2020
More Info.:Get all data from this article,  Assay Method
 
Glycogen synthase kinase-3 beta
Name:Glycogen synthase kinase-3 beta
Synonyms:GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:Enzyme
Mol. Mass.:46756.38
Organism:Homo sapiens (Human)
Description:P49841
Residue:420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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  Blast E-value cutoff:
BDBM293490
n/a
NameBDBM293490
Synonyms:US10106527, Compound 106 | US10544128, Compound 106 | US11548872, Compound 106 | US20230286945, Compound 106 | US9951048, Compound 106
TypeSmall organic molecule
Emp. Form.C21H19N5O
Mol. Mass.357.4085
SMILESCn1cc(cn1)-c1ccc2cnc(NC(=O)CCc3cccnc3)cc2c1
Structure
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